Jakob Woessmann

This paper develops an efficient workflow for spatial proteomics on FFPE tissue using low-input material, showing that EpCAM staining improves protein identification compared to H&E staining.

This paper introduces AbTags, a method to enhance detection of low-abundant proteins in single-cell proteomics by mass spectrometry through antibody-based signal amplification.

The paper introduces iDIA, a method that enhances sensitivity for quantifying regulatory proteins in single cells, revealing lineage priming and cell-cycle coordination in hematopoietic stem and progenitor cells.

This study evaluates the Orbitrap Astral MS's sensitivity for single-cell proteomics, showing improved proteome coverage and quantitative accuracy in low-input samples.

The paper evaluates the impact of different trypsin variants on proteomics experiments across multiple sample types and methods, identifying variations in performance and providing handling recommendations.