Wolfgang E. Schleicher

This study shows that Trisomy 21 reduces ciliary SMO and increases GPR161 in SHH signaling, but extended ciliary maturation normalizes these levels between T21 and D21 cells.

This study shows that aberrant oxidative metabolism drives the selection of TET2-deficient hematopoietic stem and progenitor cells in clonal hematopoiesis, with the pentose phosphate pathway playing a compensatory role.