Aberrant oxidative metabolism selects for TET2-deficient hematopoietic stem and progenitor cells
Katia E. Niño, Vera Ademà, Alyx E. Gray, Courtney M Cowan, Wolfgang E. Schleicher, Mohsen Hosseini, Sierra N. Bennett, Sweta B. Patel, Steven Moreira, Etienne P. Danis, Feyiang Ma, Hsin-Ying Lin, Tracy N. Young, Colin A. Anderson, Devyani Sharma, , Eric Martin Pietras
This study shows that aberrant oxidative metabolism drives the selection of TET2-deficient hematopoietic stem and progenitor cells in clonal hematopoiesis, with the pentose phosphate pathway playing a compensatory role.
bioRxiv · Mar 2, 2026 · PreprintCancer Biology