Cayla E Jewett

This study shows that Trisomy 21 reduces ciliary SMO and increases GPR161 in SHH signaling, but extended ciliary maturation normalizes these levels between T21 and D21 cells.

This study shows DNA damage response pathways are essential for multiciliated cell differentiation by enabling centriole amplification through a pseudo-cell cycle mechanism.

The paper introduces an optimized AID system for reversible and sustained protein degradation in live mice, demonstrating its effectiveness in degrading CEP192 and causing cell division failure.

This study shows that HYLS1 mutations cause centriole structural defects leading to ciliary dysfunction and developmental issues in mice, mirroring human Hydrolethalus Syndrome.

This study shows the MCC cell cycle variant accelerates centriole biogenesis by overlapping two cycles to produce multiple mature centrioles without cell division.