Author

Estibaliz Capetillo‐Zarate

IkerbasqueORCID 0000-0002-8416-0495Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Approach:experimental assay· 5 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Organism:human· 1

Frequent Co-Authors

Elena M AlberdiiD· 3 shared Adhara Gaminde‐BlascoiD· 2 shared Carlos MatuteiD· 2 shared Celia LuchenaiD· 2 shared Federico Nicolás SoriaiD· 2 shared Jorge ValeroiD· 2 shared Ahmed M. OsmaniD· 1 shared Ainhoa Plaza‐ZabalaiD· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersNeuroscience

Elena M AlberdiORCID

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Intravital pH Imaging using the sensor ApHID Reveals Incomplete Lysosomal Acidification in Resident Meningeal Phagocytes.

Santiago Solé‐Domènech, Sung Ji Ahn, Michael Iskols, Estibaliz Capetillo‐Zarate, Lucy Funes, Jordi Pedragosa, Carles Justicia, Lynn-Marie Johnson, J. David Warren, Anna Maria Planas, Josef Anrather, Costantino Iadecola, Frederick R. Maxfield

The paper uses ApHID-dextran to measure lysosomal pH in mouse meningeal phagocytes, revealing incomplete acidification and changes under pathological conditions.

bioRxiv · Sep 18, 2026 · PreprintNeuroscience

An Integrated Neuroimmune Assembloid Model to Advance Neurodegenerative Disease Studies

Iratxe Ruiz-Formoso, Ikerne Martin-Ferrer, Nerea Urrestizala-Arenaza, Estibaliz Capetillo‐Zarate, Fabio Cavaliere, Paula Ramos‐Gonzalez

This paper introduces neuroimmune assembloids, brain organoids with functional microglia-like cells, to study neuroimmune interactions in age-related neurodegenerative diseases.

bioRxiv · May 1, 2026 · PreprintNeuroscience

PKC-dependent MYRF dysregulation links Aβ pathology to oligodendrocyte, myelin and cognitive alterations in Alzheimer's disease

Uxue Balantzategi, Adhara Gaminde‐Blasco, Neus Alcañiz, Juanma Ramírez, Rodrigo Senovilla-Ganzo, Nagore Hernández-Pinedo, Mario Fernandez-Ballester, Federico Nicolás Soria, Alerie Guzman de la Fuente, Fernando García‐Moreno, Estibaliz Capetillo‐Zarate, Ugo Mayor, Edgar Soria Gómez, Jose Luis Zugaza, Elena M Alberdi

This study identifies MYRF dysregulation as a mechanism linking Aβ pathology to oligodendrocyte and cognitive impairments in Alzheimer's disease, showing that PKC inhibition can restore myelin and cognition.

bioRxiv · Dec 11, 2025 · PreprintNeuroscience

The nonlinear meccano of hyperactivity in Alzheimer

Giulio Bonifazi, Celia Luchena, Adhara Gaminde‐Blasco, Carolina Ortiz-Sanz, Estibaliz Capetillo‐Zarate, Carlos Matute, Elena M Alberdi, Maurizio De Pittà

This study uses biophysical modeling to explore how nonlinear molecular interactions contribute to neuronal hyperactivity in early Alzheimer's disease, revealing diverse mechanisms that may explain different AD manifestations.

bioRxiv · Oct 9, 2023 · PreprintNeuroscience

Microglial phagocytosis dysfunction during stroke is prevented by rapamycin

Sol Beccari, Virginia Sierra‐Torre, Jorge Valero, Marta Pereira‐Iglesias, Mikel García-Zaballa, Federico Nicolás Soria, Laura De Las Heras-García, Alejandro Carretero‐Guillén, Estibaliz Capetillo‐Zarate, Marı́a Domercq, Paloma R. Huguet, David Ramonet, Ahmed M. Osman, Wei Han, Cecilia A Dominguez, , Amanda Sierra

This study shows that microglial phagocytosis dysfunction during stroke is prevented by rapamycin, highlighting its potential as a therapeutic target.

Autophagy · Jan 9, 2023Peer-reviewedNeuroscience

A neuron, microglia, and astrocyte triple coculture model to study Alzheimer disease

Celia Luchena, Jone Zuazo-Ibarra, Jorge Valero, Carlos Matute, Elena M Alberdi, Estibaliz Capetillo‐Zarate

The paper develops a triple co-culture model of neurons, microglia, and astrocytes to study Alzheimer's disease, showing reduced inflammation and synaptic loss in response to Aβ.

bioRxiv · Dec 13, 2021 · PreprintNeuroscience