Klas Blomgren

Spatial immune profiling reveals lymphocyte confinement to myeloid-mesenchymal niches and heterogeneous therapeutic T-cell opportunity in pediatric ependymoma

The paper uses spatial transcriptomics to analyze immune infiltration in pediatric ependymoma, revealing compartmentalized immune niches and heterogeneous T-cell therapy opportunities.

Spatial mapping of pediatric brain tumors across diagnoses and relapses

The paper creates a spatial transcriptomic atlas of pediatric brain tumors, identifying spatial archetypes and relapse-associated clones across multiple diagnoses.

Acute activation of autophagy enables growth plate regeneration following radiation-induced injury.

The paper shows that autophagy activation helps regenerate growth plates after radiation injury, offering a potential therapeutic target.

Human growth plates house resting zone sub-populations with features of quiescent stem cells

This study characterizes gene expression in human growth plates, identifying novel markers and sub-populations of resting zone chondrocytes with features of quiescent stem cells.

Metabolic and transcriptional adaptations to phagocytosis in microglia sustain their functionality and regenerative properties

The paper investigates metabolic and transcriptional changes in microglia after phagocytosis, showing these adaptations sustain their functionality and regenerative properties.

Glioma-induced DNMT3A-dependent reduction of DNA methylation in microglia promotes a transient anti-tumoral phenotype.

This study shows that glioma-induced DNMT3A reduction in microglia leads to DNA demethylation and an anti-tumoral phenotype, suggesting DNMT3A as a therapeutic target for glioblastoma.

Microglia Adopt Temporally Specific States after Irradiation, Correlating with Neuronal Asynchrony

This study tracks microglial state changes and neuronal asynchrony after irradiation in mice, showing delayed microglial responses and two phases of neuronal dysfunction.

Unraveling Microglial Spatial Organization in the Developing Human Brain with DeepCellMap, a Deep Learning Approach Coupled to Spatial Statistics

The paper introduces DeepCellMap, a deep learning tool for analyzing spatial cellular organization in developing brains, revealing microglial phenotypes and spatial clustering patterns.

Association of microglia loss with hippocampal network impairments as a turning point in the amyloid pathology progression.

The paper investigates how microglia loss in the hippocampus contributes to early amyloid pathology progression by disrupting neural oscillations and synaptic function in a mouse model.

Microglial phagocytosis dysfunction during stroke is prevented by rapamycin

This study shows that microglial phagocytosis dysfunction during stroke is prevented by rapamycin, highlighting its potential as a therapeutic target.

Arg1+ microglia are critical for shaping cognition in female mice

This study identifies Arg1+ microglia as a distinct subtype in female mice, showing their role in cognitive function through dendritic spine maturation and behavior.

Lithium treatment reverses irradiation-induced changes in rodent neural progenitors

This study shows lithium treatment can reverse irradiation-induced impairments in hippocampal neurogenesis in mice even when started weeks after irradiation.