Fernando García‐Moreno

This study identifies MYRF dysregulation as a mechanism linking Aβ pathology to oligodendrocyte and cognitive impairments in Alzheimer's disease, showing that PKC inhibition can restore myelin and cognition.

This study identifies a proliferative-to-quiescent switch in microglial development and links it to epigenetic regulation and phagocytic function.

This paper integrates five vertebrate single-cell multi-omic atlases to reveal a conserved cellular blueprint and dual evolutionary constraints underlying early brain conservation across vertebrates.

The paper investigates metabolic and transcriptional changes in microglia after phagocytosis, showing these adaptations sustain their functionality and regenerative properties.

This study shows GABAB receptors have dual roles in oligodendrocyte function and immune modulation in experimental MS, with baclofen showing therapeutic potential in reducing disease severity and promoting remyelination.

The paper shows Notch signaling epigenetically primes neural progenitors to enhance Sonic Hedgehog signaling and promote oligodendrocyte differentiation in the developing mouse forebrain.

This study compares the development and evolution of sensory circuits in the pallium of birds, lizards, and mammals, revealing divergent developmental trajectories but functional similarity in sensory processing.

The paper characterizes the avian pallium's cell types and evolution using single-cell and spatial transcriptomics, revealing conserved and divergent features across amniotes.

This study shows that amyloid-beta oligomers disrupt RNA dynamics in oligodendrocytes by altering hnRNP A2 interactions, leading to increased translation of myelin proteins MBP and MOBP.

The paper identifies hippocampal reactive neural stem cells (react-NSCs) as phagocytic and immunologically active cells in two pathological models, MTLE and TBI.

This study shows that adult hippocampal neural stem cells (aNSCs) form in the early postnatal dentate gyrus and require cyclin D2 for their development.

The paper introduces an open-source method for high-throughput in-situ transcriptomics and provides a computational workflow for data analysis.

BirthSeq isolates and analyzes cells based on their birth date across vertebrate tissues, enabling temporal studies of cell fate in development.

The paper identifies functionally conserved non-homologous lncRNAs across species using k-mer content and structural analysis, validated through CRISPR Display in human and chicken cells.

The paper links hubness in brain networks to embryonic neurogenesis, showing that earlier-born nodes become stronger hubs and are associated with genes related to neurological diseases.

The paper identifies a pre-OPC state and a gene regulatory network involving Ascl1 that drives oligodendrocyte fate specification in Shh-responsive neocortical progenitors.

The paper develops a mathematical model of cortical neurogenesis to show that neuronal output can increase without a proportional increase in the founder population size.