Maxwell Departee

The paper integrates transcriptomic, morphological, and electrophysiological data to define neuron types in mouse visual cortex and predict their projection targets.

This study shows that cell type-specific AADC expression in Parkinson's disease models reduces motor deficits and dyskinesia more effectively than broad targeting.

The paper presents an enhancer AAV toolbox for targeting and perturbing striatal cell types and circuits in mice, with validated specificity and cross-species applicability.

The paper develops a toolkit of transgenic mouse lines and enhancer AAVs for selective targeting of cortical cell populations using transcriptomic and epigenomic data.

The paper identifies cell-type-specific molecular signatures of aging in a brain-wide transcriptomic atlas of mice, revealing key changes in non-neuronal cells and specific regions like the hypothalamic third ventricle.

The paper shows that visual areas differentially encode temporal context and expectation in natural scenes, with representational drift observed in lower areas but not higher ones.

The paper identifies diverse functional neuron types in the visual cortex that process novel and familiar stimuli in mice.