Disease-associated mutations directionally modulate epigenetic age in iPSC-derived tissues
Nicholas J. Skvir, Todd W. Dowrey, Samuel F. Cranston, Elise MacDonald, Richard M. Giadone, Dakota L. Jones, Carly S. Golden, Braden Pate, Madeline Labott, Maria Angeles Serrano, Konstantinos–Dionysios Alysandratos, Kim Vanuytsel, George J. Murphy
This study shows disease-associated mutations can directionally alter epigenetic age in iPSC-derived organoids, providing a model to study aging and disease interactions.
bioRxiv · Oct 4, 2026 · PreprintGenomics