Cell BiologybioRxivPreprint
Induction of Moderate DNA Damage Enhances Megakaryopoiesis and Platelet Production
Roelof Hendrik Bekendam, Virginia Camacho, Andrew P. Stone…·Kellie R. Machlus
The paper shows that low-dose PARP inhibitors or gamma-irradiation increase DNA damage in megakaryocytes and their progenitors, leading to higher megakaryopoiesis and platelet production in mice.