Virginia Camacho

The paper identifies MHC II-expressing bone marrow megakaryocytes as noncanonical antigen-presenting cells capable of activating CD4+ T cells and modulating immune responses.

The paper shows that inhibiting RhoA-mediated secretory autophagy in megakaryocytes reduces cytokine secretion and fibrosis in a mouse model of myelofibrosis.

This study shows glutamine supports autoimmune disease in Foxp3 deficiency by fueling biosynthetic pathways in T and B cells, with distinct roles in cytokine production and autoantibody formation.

The paper shows that low-dose PARP inhibitors or gamma-irradiation increase DNA damage in megakaryocytes and their progenitors, leading to higher megakaryopoiesis and platelet production in mice.