Joseph E. Italiano

The paper identifies MHC II-expressing bone marrow megakaryocytes as noncanonical antigen-presenting cells capable of activating CD4+ T cells and modulating immune responses.

The paper shows that inhibiting RhoA-mediated secretory autophagy in megakaryocytes reduces cytokine secretion and fibrosis in a mouse model of myelofibrosis.

The paper identifies emperipolesis as a process where megakaryocytes transfer proteins to neutrophils, enhancing their immune function and migration.

The paper shows that low-dose PARP inhibitors or gamma-irradiation increase DNA damage in megakaryocytes and their progenitors, leading to higher megakaryopoiesis and platelet production in mice.

This study shows shear stress increases platelet glycosidase activity, leading to glycosylation remodeling, platelet count decline, and microvesiculation in MCS patients.