Induction of Moderate DNA Damage Enhances Megakaryopoiesis and Platelet Production
Roelof Hendrik Bekendam, Virginia Camacho, Andrew P. Stone, María N. Barrachina, Siobhan Laken Branfield, Estelle Carminita, Isabelle C. Becker, Dong Hoon Lee, Ethan Walsey, Clementine Payne, Jakub Kaplan, Julia Tilburg, Sharmistha Pal, Luís F.Z. Batista, Joseph E. Italiano, Kellie R. Machlus
The paper shows that low-dose PARP inhibitors or gamma-irradiation increase DNA damage in megakaryocytes and their progenitors, leading to higher megakaryopoiesis and platelet production in mice.
bioRxiv · May 8, 2025 · PreprintCell Biology