Author

Estelle Carminita

Boston Children's HospitalORCID 0000-0002-8544-4879Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:ATAC-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Dong Hoon LeeiD· 2 shared Isabelle C. BeckeriD· 2 shared Joseph E. ItalianoiD· 2 shared Kellie R. MachlusiD· 2 shared María N. BarrachinaiD· 2 shared Virginia CamachoiD· 2 shared Andrew P. StoneiD· 1 shared Chen WengiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersImmunology

Dong Hoon LeeORCID

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2 papers

Recent·Most cited

MHC II-expressing bone marrow megakaryocytes are noncanonical antigen presenting cells and activate CD4+ T cells ex vivo

Virginia Camacho, Karen G. Wang, Pavel Hanč, Estelle Carminita, Isabelle C. Becker, Dong Hoon Lee, Mahmoud Adel Bassal, Marcelo Falchetti, Jaxaira Maggi, María N. Barrachina, Ulrich H. von Andrian, Montserrat Carrascal, Deepa Gautam, Chen Weng, Vijay G. Sankaran, , Kellie R. Machlus

The paper identifies MHC II-expressing bone marrow megakaryocytes as noncanonical antigen-presenting cells capable of activating CD4+ T cells and modulating immune responses.

Cell Reports · Oct 30, 2026Peer-reviewedImmunology

Induction of Moderate DNA Damage Enhances Megakaryopoiesis and Platelet Production

Roelof Hendrik Bekendam, Virginia Camacho, Andrew P. Stone, María N. Barrachina, Siobhan Laken Branfield, Estelle Carminita, Isabelle C. Becker, Dong Hoon Lee, Ethan Walsey, Clementine Payne, Jakub Kaplan, Julia Tilburg, Sharmistha Pal, Luís F.Z. Batista, Joseph E. Italiano, Kellie R. Machlus

The paper shows that low-dose PARP inhibitors or gamma-irradiation increase DNA damage in megakaryocytes and their progenitors, leading to higher megakaryopoiesis and platelet production in mice.

bioRxiv · May 8, 2025 · PreprintCell Biology