Author

Andrew P. Stone

Boston Children's HospitalORCID 0000-0002-1087-9923Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

Ethan Walsey· 2 shared Isabelle C. BeckeriD· 2 shared Joseph E. ItalianoiD· 2 shared Kellie R. MachlusiD· 2 shared María N. BarrachinaiD· 2 shared Siobhan Laken BranfieldiD· 2 shared Virginia CamachoiD· 2 shared Alasdair G. KayiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCell Biology

Ethan Walsey

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Inhibition of RhoA-mediated secretory autophagy in megakaryocytes mitigates myelofibrosis in mice

Isabelle C. Becker, Siobhan Laken Branfield, María N. Barrachina, Virginia Camacho, Joshua T. Lykins, Andrew P. Stone, Ethan Walsey, Muhammad Bennani, Bernadette Anne Chua, Robert A. J. Signer, Kellie R. Machlus, Sidney W. Whiteheart, Harvey G. Roweth, Joseph E. Italiano

The paper shows that inhibiting RhoA-mediated secretory autophagy in megakaryocytes reduces cytokine secretion and fibrosis in a mouse model of myelofibrosis.

Nature Communications · Aug 13, 2026Peer-reviewedCell Biology

Extracellular vesicle bioactivity and potential clinical utility is determined by mesenchymal stromal cell clonal subtype

Savvas Ioannou, Alasdair G. Kay, Andrew P. Stone, Emma Rand, Samuel Elberfeld, William Bolton, Tony R. Larson, Rachel E. Crossland, Oksana Kehoe, David A. Mentlak, Xiao-Nong Wang, Chris MacDonald, Paul G. Genever

This study compares EV bioactivity and clinical utility from two clonal MSC subtypes, finding Y201 EVs show enhanced proliferation effects and in vivo efficacy compared to Y202 EVs.

Stem Cell Research & Therapy · Oct 16, 2025Peer-reviewedCell Biology

Induction of Moderate DNA Damage Enhances Megakaryopoiesis and Platelet Production

Roelof Hendrik Bekendam, Virginia Camacho, Andrew P. Stone, María N. Barrachina, Siobhan Laken Branfield, Estelle Carminita, Isabelle C. Becker, Dong Hoon Lee, Ethan Walsey, Clementine Payne, Jakub Kaplan, Julia Tilburg, Sharmistha Pal, Luís F.Z. Batista, Joseph E. Italiano, Kellie R. Machlus

The paper shows that low-dose PARP inhibitors or gamma-irradiation increase DNA damage in megakaryocytes and their progenitors, leading to higher megakaryopoiesis and platelet production in mice.

bioRxiv · May 8, 2025 · PreprintCell Biology