Author

Iga Kucharska

Hospital for Sick ChildrenORCID 0000-0001-6150-3419Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:C. elegans· 1 Research Focus:drug response / drug discovery· 1 Organism:plant (other)· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Jean‐Philippe JulieniD· 3 shared John L. RubinsteiniD· 3 shared Hong Cui· 2 shared Amy NouanesengsyiD· 1 shared Anthony Semesi· 1 shared Bebhinn TreanoriD· 1 shared Clare Burn AschneriD· 1 shared Daniel SchramekiD· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersMolecular Biology

Jean‐Philippe JulienORCID

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3 papers

Recent·Most cited

Molecular BiologyeLifePeer-reviewedJan 13, 2022

Structural basis of Plasmodium vivax inhibition by antibodies binding to the circumsporozoite protein repeats

Iga Kucharska, Lamia Hossain, Danton Ivanochko…·Jean‐Philippe Julien

This study reveals the structural basis of Plasmodium vivax inhibition by antibodies targeting the CSP repeats through molecular dynamics simulations and crystal structure analysis of inhibitory monoclonal antibodies.

21 citations

plant (other)protein structure

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Molecular BiologyNature CommunicationsPeer-reviewedJun 16, 2021

Multivalency transforms SARS-CoV-2 antibodies into broad and ultrapotent neutralizers

Edurne Rujas, Iga Kucharska, Yong Zi Tan…·Jean‐Philippe Julien

The paper describes a multimerization platform that transforms antibodies into potent, broad-spectrum neutralizers against SARS-CoV-2.

78 citationstop 4%

experimental assaydrug response / drug discovery

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Molecular BiologybioRxivPreprintDec 10, 2019

Identification of the C. sordellii lethal toxin receptor elucidates principles of receptor specificity in clostridial toxins

Hunsang Lee, Greg L. Beilhartz, Iga Kucharska…·Mikko Taipale

The paper identifies SEMA6A and SEMA6B as receptors for C. sordellii lethal toxin and shows how mutations can switch receptor specificity between related toxins.

DOI 10.1101/871707

C. elegansexperimental assay

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