Moritz Kueblbeck

This study uses time-resolved single-cell CRISPR screening and a multiome atlas to uncover dynamic gene regulatory networks in human cardiogenesis, identifying stage-specific regulators and CHD-linked gene functions.

This paper introduces SDR-seq, a multiomic scDNA-scRNA-seq method to link genotypes with gene expression, showing variants affect expression in iPSCs and B-cell lymphoma.

This paper describes an engineered nanobody that modulates GFP binding with small molecules, enabling controlled study of GFP fusion proteins in biological processes.

The paper develops a framework to create a dynamic protein atlas of human cell division by integrating 4D imaging data with computational modeling.

The paper describes a protocol to generate and validate homozygous fluorescent knock-in cell lines using CRISPR/Cas9 and provides validation methods to ensure accuracy and functionality.

This study demonstrates that CTCF, WAPL, and PDS5 proteins regulate TADs and loops by controlling cohesin's interaction with chromatin.