Birgit Koch

This paper introduces a high-affinity split-HaloTag system for live-cell protein labeling, enabling efficient and versatile imaging with compatibility for advanced microscopy techniques.

The paper introduces CLIP-tag2, an engineered variant of the CLIP-tag protein that significantly improves labeling speed and efficiency for live-cell imaging.

The paper introduces SiR-XActin, a far-red fluorescent probe for imaging actin dynamics in live cells with minimal cytotoxicity and without genetic modifications.

This paper introduces a family of tunable calcium indicators with fluorescence and bioluminescence readouts, applicable for live-cell imaging and high-throughput assays in rat neurons.

This paper describes an engineered nanobody that modulates GFP binding with small molecules, enabling controlled study of GFP fusion proteins in biological processes.

The paper develops a framework to create a dynamic protein atlas of human cell division by integrating 4D imaging data with computational modeling.

The paper describes a protocol to generate and validate homozygous fluorescent knock-in cell lines using CRISPR/Cas9 and provides validation methods to ensure accuracy and functionality.

This paper presents a workflow combining FCS-calibrated imaging and 4D microscopy to quantitatively map protein concentrations and copy numbers in live cells.

This study demonstrates that CTCF, WAPL, and PDS5 proteins regulate TADs and loops by controlling cohesin's interaction with chromatin.