Jan Ellenberg

The paper shows hydrophobic FG-nucleoporins dilate nuclear pores during mitosis, enabling nuclear import and NE reformation.

This paper identifies senescence-induced CTCF clusters (SICCs) and shows they sustain the senescence splicing program by repurposing nuclear speckle components.

This study uses nanoscale DNA tracing to show that mitotic chromosomes form through self-organization via large, overlapping loops driven by Condensins.

The paper introduces an integrative spatiotemporal modeling method for dynamic biomolecular processes, applied to Nuclear Pore Complex assembly, improving model precision over static approaches.

The paper shows Cohesin replaces Condensin to rebuild genome architecture after mitosis, forming nested loop structures.

The paper introduces a simulation pipeline to generate structurally variable synthetic NPCs for benchmarking image analysis methods and understanding NPC variability in SMLM data.

This study develops an engineered uterus-like microenvironment to study mouse embryo implantation, revealing coordination between trophoblast migration and embryo growth.

This paper describes an engineered nanobody that modulates GFP binding with small molecules, enabling controlled study of GFP fusion proteins in biological processes.

The paper develops a framework to create a dynamic protein atlas of human cell division by integrating 4D imaging data with computational modeling.

The paper describes a protocol to generate and validate homozygous fluorescent knock-in cell lines using CRISPR/Cas9 and provides validation methods to ensure accuracy and functionality.

This paper presents a workflow combining FCS-calibrated imaging and 4D microscopy to quantitatively map protein concentrations and copy numbers in live cells.

The paper develops ChromoTrace, a method to reconstruct 3D chromosome configurations from super-resolution microscopy images with high accuracy and sensitivity.

This study demonstrates that CTCF, WAPL, and PDS5 proteins regulate TADs and loops by controlling cohesin's interaction with chromatin.