Author

R. Blake Hill

Medical College of WisconsinORCID 0000-0001-6228-3905Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:imaging· 1 Approach:machine learning (classical)· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

Elizabeth Wei-Chia LuoiD· 2 shared Gerard C. L. WongiD· 2 shared Haleh AlimohamadiiD· 2 shared Kelsey A NoldeniD· 2 shared Liting DuaniD· 2 shared Amanda M. TravisiD· 1 shared Erica H Rodas Montejo· 1 shared Kyle A. RossiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBiophysics

Elizabeth Wei-Chia LuoORCID

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3 papers

Recent·Most cited

BiophysicsbioRxivPreprintOct 6, 2026

Pathogenic DRP1 variants reveal a role for biomolecular condensation in mitochondrial fission

Kyle A. Ross, Amanda M. Travis, Megan Cleland Harwig…·R. Blake Hill

This study shows pathogenic DRP1 variants impair mitochondrial fission by affecting biomolecular condensation, revealing a new regulatory mechanism.

DOI 10.64898/2026.07.06.735726

𝕏 PostBluesky

BiophysicsJournal of the American Chemical SocietyPeer-reviewedJul 8, 2025

Drp1 Proteins Released from Hydrolysis-driven Scaffold Disassembly Trigger Nucleotide-dependent Membrane Remodeling to Promote Scission

Elizabeth Wei-Chia Luo, Kelsey A Nolden, Haleh Alimohamadi…·Gerard C. L. Wong

The paper investigates the mechanism of mitochondrial fission by Drp1, showing that GTP hydrolysis enables free Drp1 to induce membrane negative Gaussian curvature, promoting scission.

4 citations

machine learning (classical)cell signaling & trafficking

𝕏 PostBluesky

BiophysicsJournal of the American Chemical SocietyPeer-reviewedJul 8, 2025

Dynamins combine mechano-constriction and membrane remodeling to enable two-step mitochondrial fission via a snap-through instability.

Haleh Alimohamadi, Elizabeth Wei-Chia Luo, Xiaoying Liu…·Gerard C. L. Wong

This study shows how dynamin proteins use mechano-constriction and membrane curvature to drive mitochondrial fission through a snap-through instability.

4 citations

mechanistic / dynamical modelcell signaling & trafficking

𝕏 PostBluesky