Liting Duan

This paper introduces REDMAPCre, a red-light-activated Cre recombinase system that enables rapid and efficient DNA recombination in mammalian cells and mice.

The paper investigates the mechanism of mitochondrial fission by Drp1, showing that GTP hydrolysis enables free Drp1 to induce membrane negative Gaussian curvature, promoting scission.

This study shows how dynamin proteins use mechano-constriction and membrane curvature to drive mitochondrial fission through a snap-through instability.

This paper introduces an optogenetic method to deform mitochondria in live cells using light to recruit molecular motors, enabling precise mechano-stimulation and study of mitochondrial mechanics and function.

This paper develops optogenetic methods to activate TrkB receptors with spatial and temporal control, finding that the CRY2-based approach is most efficient.

This paper develops light-inducible methods to activate TrkA signaling without NGF, enabling precise spatial and temporal control of neuronal signaling pathways.