BiophysicsJournal of the American Chemical SocietyPeer-reviewed
Drp1 Proteins Released from Hydrolysis-driven Scaffold Disassembly Trigger Nucleotide-dependent Membrane Remodeling to Promote Scission
Elizabeth Wei-Chia Luo, Kelsey A Nolden, Haleh Alimohamadi…·Gerard C. L. Wong
The paper investigates the mechanism of mitochondrial fission by Drp1, showing that GTP hydrolysis enables free Drp1 to induce membrane negative Gaussian curvature, promoting scission.