Cell BiologybioRxivPreprint
Transient reprogramming limits AP-1-associated chromatin opening and transposable element activation to preserve hematopoietic stem cell function during aging and stress
Audrey Porquet, Mathieu Bohm, Hassan Ait-Ougouram…·Françoise Porteu
This study shows that transient reprogramming with Yamanaka factors delays and partially reverses HSC aging and stress-induced decline by limiting AP-1 chromatin opening and transposable element activation.