Oliver J. Melling

The paper designs and characterizes triazole-based peptidomimetics of the -GI conotoxin, showing they retain potency and provide structural insights into their interaction with the muscle-type nAChR.

The paper determines the molecular basis of -conotoxin specificity for muscle-type nAChRs using cryo-EM structures and computational methods.

This study determines the crystal structures of human and macaque CD1d bound to -GalCer, revealing conserved ligand-responsive conformational flexibility at Phe84 that modulates antigen presentation.