Author

Michael J. Capper

University of GlasgowORCID 0000-0003-0102-6993Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:cryo-EM· 1 Approach:deep learning· 1 Organism:human· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Andrew G. JamiesoniD· 2 shared Charlie HoldshipiD· 2 shared Christopher M. TimperleyiD· 2 shared Jeremy Graham FreyiD· 2 shared Jesko KoehnkeiD· 2 shared Jonathan W. EssexiD· 2 shared Josephine ConnahiD· 2 shared Kirsty ArnottiD· 2 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

Andrew G. JamiesonORCID

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2 papers

Recent·Most cited

Cryo-EM Structure of a Triazole alpha-Conotoxin GI Mimetic Bound to the Muscle-Type Nicotinic Acetylcholine Receptor

Oscar A. Shepperson, Michael J. Capper, Charlie Holdship, Oliver J. Melling, Nicola Wade, Michael A. Malone, Kirsty Arnott, Danielle C. Morgan, Thomas J. Piggot, Tiffany Morcom, Josephine Connah, Leonie M. Windeln, Christopher M. Timperley, Jeremy Graham Frey, Chris Green, , Andrew G. Jamieson

The paper designs and characterizes triazole-based peptidomimetics of the -GI conotoxin, showing they retain potency and provide structural insights into their interaction with the muscle-type nAChR.

bioRxiv · Sep 1, 2026 · PreprintBiochemistry

Structures of muscle-type nicotinic acetylcholine receptor with α-conotoxins reveal determinants of receptor-subtype specificity

Michael J. Capper, Oscar A. Shepperson, Charlie Holdship, Oliver J. Melling, Nicola Wade, Michael A. Malone, Kirsty Arnott, Leonie M. Windeln, Steven Turner, Charlotte L. Whitmore, Tiffany Morcom, Josephine Connah, Christopher M. Timperley, Jeremy Graham Frey, C. Green, , Andrew G. Jamieson

The paper determines the molecular basis of -conotoxin specificity for muscle-type nAChRs using cryo-EM structures and computational methods.

bioRxiv · Jan 15, 2026 · PreprintMolecular Biology