Jesko Koehnke

Cryo-EM Structure of a Triazole alpha-Conotoxin GI Mimetic Bound to the Muscle-Type Nicotinic Acetylcholine Receptor

The paper designs and characterizes triazole-based peptidomimetics of the -GI conotoxin, showing they retain potency and provide structural insights into their interaction with the muscle-type nAChR.

Acyl amides derived from a bacterial symbiont control development of its nematode host

The paper identifies bacterial acyl amides, called stripteamides, as signals controlling nematode development in the Steinernema-Xenorhabdus symbiosis.

Structures of muscle-type nicotinic acetylcholine receptor with α-conotoxins reveal determinants of receptor-subtype specificity

The paper determines the molecular basis of -conotoxin specificity for muscle-type nAChRs using cryo-EM structures and computational methods.

A fucose-binding superlectin from Enterobacter cloacae with high Lewis and ABO blood group antigen specificity

The paper identifies and characterizes a fucose-binding lectin from Enterobacter cloacae with high specificity for LewisA and blood group O antigens.