Author

Sinéad A. O’Sullivan

German Center for Neurodegenerative DiseasesORCID 0000-0003-1909-0803Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:mouse· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Ayşe UlusoyiD· 2 shared Donato A. Di MonteiD· 2 shared Adrian PerdyaniD· 1 shared Alfonso De SimoneiD· 1 shared Anass ChikiiD· 1 shared Anne‐Laure Mahul‐MellieriD· 1 shared Giuliana FuscoiD· 1 shared Hilal Ahmed LashueliD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersNeuroscience

Ayşe UlusoyORCID

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2 papers

Recent·Most cited

α-Synuclein impairs mitochondrial function and alters cryptochrome regulation in the substantia nigra

Sinéad A. O’Sullivan, Adrian Perdyan, Ayşe Ulusoy, Rita Pinto‐Costa, Shirley S. L. Lee, Urszula Ławrynowicz, Jochen H.M. Prehn, Jakub Mieczkowski, Donato A. Di Monte

This study shows that α-synuclein accumulation in dopaminergic neurons leads to mitochondrial dysfunction and changes in circadian gene expression, contributing to neuronal damage in Parkinson's disease.

bioRxiv · Aug 21, 2026 · PreprintNeuroscience

Post-fibrillization nitration of alpha-synuclein abolishes its seeding activity and pathology formation in primary neurons and in vivo

Sonia Donzelli, Sinéad A. O’Sullivan, Anne‐Laure Mahul‐Mellier, Ayşe Ulusoy, Giuliana Fusco, Senthil T. Kumar, Anass Chiki, Johannes Burtscher, Manel L. N. Boussouf, Iman Rostami, Alfonso De Simone, Donato A. Di Monte, Hilal Ahmed Lashuel

This study shows that nitration of alpha-synuclein after fibrillization reduces its seeding activity and pathology formation in neurons and in vivo.

bioRxiv · Mar 24, 2023 · PreprintNeuroscience