Adrian Perdyan

α-Synuclein impairs mitochondrial function and alters cryptochrome regulation in the substantia nigra

This study shows that α-synuclein accumulation in dopaminergic neurons leads to mitochondrial dysfunction and changes in circadian gene expression, contributing to neuronal damage in Parkinson's disease.

Spatial Transcriptomics of TNBC tumours and corresponding lymph node metastasis reveals immune hubs driven by TNF/NF-κB signalling of TMSB4X and CD74 expressing cells.

The paper uses spatial transcriptomics to identify immune hubs in TNBC lymph node metastases driven by TMSB4X and CD74, revealing spatially expanded inflammatory networks and myeloid-endothelial signaling.

Distinct small molecule inhibitors of Kras specifically prime CTLA4 blockade therapy to transcriptionally reprogram Tregs and overcome resistance to suppress pancreas cancer

This study identifies small molecule Kras inhibitors that synergize with anti-CTLA4 therapy to reprogram Tregs and enhance immunotherapy efficacy in PDAC.

p53 Regulates Nuclear Architecture to Reduce Carcinogen Sensitivity and Mutagenic Potential

The paper shows p53 maintains nuclear architecture to reduce carcinogen sensitivity and mutagenic potential by altering chromatin structure and UV lesion abundance.