Fibroblast orchestration of inflammaging via NF-kB activation
Nancy C. Allen, Christian Ringler, Jin Young Lee, Nabora S. Reyes, Ritusree Biswas, Sofia E. Caryotakis, Mélia Magnen, Pedro Ruivo, Vincent C. Auyeung, Mark R. Looney, Averil I. Ma, Ari B. Molofsky, Tien Peng
This study shows that aged fibroblasts activate NF-kB, leading to immune changes like exhausted T cells, autoimmunity, and cancer, increasing susceptibility to age-related diseases.
bioRxiv · Oct 1, 2025 · PreprintImmunology