Author

Jin Young Lee

University of California, San FranciscoORCID 0000-0002-9059-0168Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Nabora S. ReyesiD· 2 shared Nancy C. Allen· 2 shared Ritusree Biswas· 2 shared Tien PengiD· 2 shared Vincent C. AuyeungiD· 2 shared Aaron Scott MansfieldiD· 1 shared Andrew J. LechneriD· 1 shared Ari B. MolofskyiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

Nabora S. ReyesORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Senescent fibroblasts in the tumor stroma rewire lung cancer metabolism and plasticity

Jin Young Lee, Nabora S. Reyes, Sang‐Ho Woo, Nancy C. Allen, Tsukasa Kadota, Andrew J. Lechner, Ritusree Biswas, Sakshi Goel, Fia Stratton, Chaoyuan Kuang, Tatsuya Tsukui, Vincent C. Auyeung, Aaron Scott Mansfield, Lindsay M. LaFave, Tien Peng

This study identifies senescent fibroblasts in lung cancer stroma that alter tumor metabolism and plasticity, and shows that targeting these cells with XL888 reduces tumor burden.

Cell stem cell · Nov 3, 2025Peer-reviewedCancer Biology

Fibroblast orchestration of inflammaging via NF-kB activation

Nancy C. Allen, Christian Ringler, Jin Young Lee, Nabora S. Reyes, Ritusree Biswas, Sofia E. Caryotakis, Mélia Magnen, Pedro Ruivo, Vincent C. Auyeung, Mark R. Looney, Averil I. Ma, Ari B. Molofsky, Tien Peng

This study shows that aged fibroblasts activate NF-kB, leading to immune changes like exhausted T cells, autoimmunity, and cancer, increasing susceptibility to age-related diseases.

bioRxiv · Oct 1, 2025 · PreprintImmunology