Hanieh Falahati

This paper introduces pan-ExM-t, an all-optical method for visualizing specific proteins in the ultrastructural context of brain tissue, demonstrating its application on various markers in mouse brain sections and neuron cultures.

The paper shows that expressing a synaptopodin construct in non-neuronal cells generates ER stacks resembling the spine apparatus, revealing a role for synaptopodin-dependent actin matrix in their formation.

The paper investigates synaptopodin's properties and identifies its protein neighbors in dendritic spines, suggesting the spine apparatus matrix functions as a liquid condensate.

The paper shows that asynchronous release sites are positioned to enhance NMDA receptor activation by reducing magnesium block.