Eric Hosy

Affinity-guided labeling reveals P2X7 nanoscale membrane redistribution during BV2 microglial activation

The paper introduces X7-uP, a chemical labeling reagent for P2X7 receptors, enabling super-resolution imaging of their nanoscale redistribution in BV2 microglial cells during activation.

Full epistatic interaction maps retrieve part of missing heritability and improve phenotypic prediction

This paper introduces NGG, a method that efficiently identifies epistatic interactions to explain missing heritability and improve phenotype prediction.

Engineering paralog-specific PSD-95 synthetic binders as potent and minimally invasive imaging probes

The paper develops synthetic binders specific to PSD-95 for imaging endogenous proteins with minimal impact on function and compatibility with super-resolution techniques.

High-resolution imaging and manipulation of endogenous AMPA receptor surface mobility during synaptic plasticity and learning

This study uses a knock-in mouse model to monitor and manipulate AMPA receptor mobility, showing its role in synaptic plasticity and memory formation.

CaMKII activation triggers persistent formation and segregation of postsynaptic liquid phase

The paper shows that CaMKII activation leads to persistent liquid-liquid phase separation with GluN2B, forming stable postsynaptic assemblies that enhance synaptic transmission and memory formation.

Release sites are positioned to activate NMDA receptors

The paper shows that asynchronous release sites are positioned to enhance NMDA receptor activation by reducing magnesium block.

Specific nanoscale synaptic reshuffling and control of short-term plasticity following NMDAR- and P2XR-dependent Long-Term Depression

The paper investigates nanoscale synaptic changes during two LTD protocols, showing NMDAR-dependent LTD reorganizes PSD-95 to enhance synaptic facilitation.

Pre-post synaptic alignment through neuroligin tunes synaptic transmission efficiency

The paper shows that neuroligin-1 alignment with AMPA receptor nanodomains is critical for synaptic transmission efficiency, as disrupting this alignment reduces transmission.