Aaron T. Kuan

All-optical visualization of specific molecules in the ultrastructural context of brain tissue

This paper introduces pan-ExM-t, an all-optical method for visualizing specific proteins in the ultrastructural context of brain tissue, demonstrating its application on various markers in mouse brain sections and neuron cultures.

Self-supervised image restoration in coherent X-rayneuronal microscopy

This paper introduces a self-supervised image restoration method for X-ray holographic nanotomography to improve resolution, contrast, and speed in neuronal imaging.

Scalable electron tomography for connectomics

This paper demonstrates limited-tilt serial section electron tomography for high-resolution 3D mapping of brain circuits and evaluates imaging parameters for connectomic-scale projects.

Synaptic wiring motifs in posterior parietal cortex support decision-making

The paper investigates how synaptic connectivity in the posterior parietal cortex supports decision-making by identifying opponent inhibition motifs between excitatory and inhibitory neurons.

Origins of proprioceptor feature selectivity and topographic maps in the Drosophila leg

The paper investigates biomechanical and molecular mechanisms underlying proprioceptor diversity in Drosophila legs, identifying a biomechanical basis for joint angle selectivity and a goniotopic map of joint angle.

Reconstruction of motor control circuits in adult Drosophila using automated transmission electron microscopy

The paper presents a high-resolution EM dataset of Drosophila ventral nerve cord and develops GridTape for automated EM data collection, revealing a unique feedback pathway in motor control.

Dense neuronal reconstruction through X-ray holographic nano-tomography

This paper introduces X-ray holographic nano-tomography for imaging dense neuronal structures in Drosophila and mammals, using convolutional neural networks for automated segmentation.

Astrocyte-neuron crosstalk through Hedgehog signaling mediates cortical circuit assembly

This study shows that Sonic hedgehog signaling from cortical neurons regulates astrocyte development and synaptic connectivity during cortical circuit formation.

High-throughput transmission electron microscopy with automated serial sectioning

This paper introduces a high-throughput TEM imaging platform with automated serial sectioning for generating detailed biological tissue datasets, particularly for brain circuit analysis.

Brainwide organization of neuronal activity and convergent sensorimotor transformations in larval zebrafish

The paper analyzes whole-brain neuronal activity in larval zebrafish during visual stimuli and motor output, revealing functional brain nuclei and convergent sensorimotor transformations.