Xiaolin Wei

Epitope-tagged knockin mice show histone H1.4 protein accumulates in postmitotic neurons, shifts toward B-compartment heterochromatin with maturation, and H1f2/H1f4 loss impairs cerebellar granule neuron chromatin compaction.

The paper investigates transcriptional changes in VTA neurons after chronic cocaine cessation and their role in relapse, finding that BDNF transcription is causally linked to cocaine seeking.

This study identifies pro-inflammatory macrophages as a key factor impairing skeletal muscle regeneration in ischemic-damaged limbs by inducing premature differentiation of satellite cells.

The paper introduces HiCAR, a method that simultaneously assesses chromatin accessibility, interactions, and transcriptome in low-input samples, revealing 46,792 cis-regulatory interactions in H1 hESCs.