Andrew W. Truman

Acetylation of the yeast Hsp40 chaperone protein Ydj1 fine-tunes proteostasis and translational fidelity

This study identifies acetylation sites on yeast Ydj1 that affect its interactions with chaperones and client proteins, impacting proteostasis and translational fidelity.

Proteomic Analysis Defines the Interactome of Telomerase in the Protozoan Parasite, Trypanosoma brucei

The paper identifies the interactome of TERT in Trypanosoma brucei using mass spectrometry, revealing unique telomerase interactions in this parasite.

The C-terminal domain of Hsp70 is responsible for paralog-specific regulation of ribonucleotide reductase

The paper shows that the C-terminal domain of Hsp70 paralogs Ssa3 and Ssa4 specifically regulates ribonucleotide reductase, affecting DNA damage resistance and RNR subunit stability.

A novel multifunctional role for Hsp70 in binding post-translational modifications on clients

This paper uses cross-linking mass spectrometry to characterize Hsp70 interactions in budding yeast, revealing self-association, multi-point client interactions, and novel PTMs critical for client function.