Author

James C. Cronk

National Institutes of HealthORCID 0000-0001-6401-0740Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

Rosandra Natasha KaplaniD· 2 shared Aaron Y. MochizukiiD· 1 shared Amy B. HeimbergeriD· 1 shared Amy Kathleen LeBlanciD· 1 shared Anandani NellaniD· 1 shared Ashley CardamoneiD· 1 shared Brad St. CroixiD· 1 shared Carly M. SayersiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersImmunology

Rosandra Natasha KaplanORCID

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3 papers

Recent·Most cited

Murine modeling of IDH-mutant 1p/19q-codeleted oligodendroglioma reveals genotype specific phenotypes

Ipsita G. Kundu, Nicolas Toro, Aaron Y. Mochizuki, Jaldeep Langhnoja, Rithvik V Ayyagari, James C Cronk, Sarah Martin Reel, Phonepasong Arounleut, Luis Tron Esqueda, Christine E. Fuller, Pavithra Viswanath, Amy B. Heimberger, Craig Horbinski, Timothy N. Phoenix

This study creates a mouse model of IDH-mutant 1p/19q-codeleted oligodendroglioma and identifies genotype-specific phenotypes and molecular features.

Neuro-Oncology · Sep 17, 2026Peer-reviewedCancer Biology

Engineering Functionality-Optimized Fully Human B7-H3 CAR T Cells for Enhanced Solid Tumor Therapy

Pradip Bajgain, Yang Feng, Mariela Puebla, Meijie Tian, Kuo-Sheng Hsu, Jaewon Lee, Guojun Yu, Liping Yang, Steven Seaman, Mary Beth Hilton, Karen Morris, Niza Borchin, Jennifer D. Tran, Riley D. Metcalfe, Dan Li, , Brad St. Croix

This study develops fully human B7-H3 CAR T cells using phage display, showing improved antitumor activity and reduced immune response in xenograft models.

Cell Reports Medicine · May 1, 2026Peer-reviewedImmunology

Spatial profiling identifies regionally distinct microenvironments and targetable immunosuppressive mechanisms in pediatric osteosarcoma pulmonary metastases.

Jason Eigenbrood, Nathan W. Wong, Paul W. Mallory, Janice S. Pereira, Demond Williams, Douglass W. Morris-II, Jessica A. Beck, James C. Cronk, Carly M. Sayers, Monica Mendez, Linus Kaiser, Julie Galindo, Jatinder Singh, Ashley Cardamone, Milind M. Pore, , Troy A. McEachron

Visium profiling of nine pediatric osteosarcoma pulmonary metastases reveals a conserved granuloma-like architecture: inflamed macrophage-rich periphery, collagen capsule, inflammation-poor core, and CXCR4 as candidate target.

Cancer Research · Apr 2, 2025Peer-reviewedCancer Biology✦ In-depth digest