Author

Brad St. Croix

National Institutes of HealthORCID 0000-0002-6246-0374Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Anandani NellaniD· 1 shared Brad BelliD· 1 shared Dan Li· 1 shared Elizabeth A. BrooksiD· 1 shared Francesco RaimondiiD· 1 shared Guojun YuiD· 1 shared Ireolu K. OrenugaiD· 1 shared Jaewon Lee· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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1 shared paperImmunology

Anandani NellanORCID

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3 papers

Recent·Most cited

ImmunologyCell Reports MedicinePeer-reviewedMay 1, 2026

Engineering Functionality-Optimized Fully Human B7-H3 CAR T Cells for Enhanced Solid Tumor Therapy

Pradip Bajgain, Yang Feng, Mariela Puebla…·Brad St. Croix

This study develops fully human B7-H3 CAR T cells using phage display, showing improved antitumor activity and reduced immune response in xenograft models.

3 citationstop 2%

mouseexperimental assay

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Cancer BiologyCancer ResearchPeer-reviewedDec 29, 2025

Dissection of Gαs and Hedgehog signaling crosstalk reveals therapeutic opportunities to target adenosine receptor 2b in Hedgehog-dependent tumors

Sarah Krantz, Brad Bell, Katherine Lund…·Ramiro Iglesias‐Bartolomé

The paper identifies Gs pathway inactivation as an SMO-independent Hedgehog signaling driver in BCC and shows adenosine 2B receptor activation can counteract SMO-driven oncogenesis.

1 citation

mousebulk RNA-seq

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BioengineeringCancer ResearchPeer-reviewedJan 29, 2025

Engineering Tumor Stroma Morphogenesis Using Dynamic Cell-Matrix Spheroid Assembly

Michael J. Buckenmeyer, Elizabeth A. Brooks, Madison S. Taylor…·Matthew T. Wolf

This paper develops a 3D self-assembly system to engineer tumor stroma-like structures using decellularized ECM and cancer cells, showing effects on malignancy and metabolism.

9 citationstop 4%

humanmouse

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