MicrobiologybioRxivPreprint
Nanobody-mediated modulation of long RSH enzymes Rel and RelA catalysis by restriction of their conformational landscape
Katleen Van Nerom, Andres Ainelo, Kyo Coppieters ’t Wallant…·Abel García-Pino
This study identifies nanobodies that modulate Rel and RelA enzyme activity by trapping them in specific conformational states, inhibiting (p)ppGpp synthesis and affecting bacterial virulence.
DOI 10.1101/2025.08.07.669093