Kyo Coppieters ’t Wallant

This study uses HDX-MS to show that local conformational plasticity in MFS transporters enables ligand recognition and proton coupling, revealing dynamic adaptations beyond static structures.

This study reports crystal structures of the QacA efflux pump in different conformational states, revealing structural dynamics and mechanisms of multidrug transport and extrusion.

This study identifies nanobodies that modulate Rel and RelA enzyme activity by trapping them in specific conformational states, inhibiting (p)ppGpp synthesis and affecting bacterial virulence.

This study shows that the bacterial immunity protein CapRelSJ46 can sense two distinct phage proteins using the same domain, highlighting its versatility in anti-phage defense.

This study identifies and characterizes two Escherichia coli TAC systems that mediate antiphage defense by recognizing phage proteins and modifying mRNA to inhibit translation.