Author

Dexter W. Adams

Howard Hughes Medical Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Developmental Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:DNA methylation· 2 Organism:C. elegans· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Leemor Joshua‐ToriD· 2 shared Benjamin BerubeiD· 1 shared Brian A. KinneyiD· 1 shared Chantal LeBlanciD· 1 shared Christopher M. HammelliD· 1 shared Daniel GrimanelliiD· 1 shared David Arthur TuvesoniD· 1 shared Douglas T. FearoniD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersMolecular Biology

Leemor Joshua‐TorORCID

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3 papers

Recent·Most cited

Signal peptide-independent secretion of keratin-19 by pancreatic cancer cells

Philip Moresco, Jonathan P. Kastan, Jung‐In Yang, Rishvanth K. Prabakar, Z. Larkin Kelley, Francesca Minicozzi, Dexter W. Adams, Paolo Cifani, David Arthur Tuveson, Douglas T. Fearon

This study shows pancreatic cancer cells secrete keratin-19 (KRT19) without a signal peptide by entering the ER via its head domain and through secretory autophagy, enabling CXCL12 capture to exclude T cells.

Proceedings of the National Academy of Sciences · Jul 1, 2025Peer-reviewedCell Biology

Chromatin remodeling of histone H3 variants underlies epigenetic inheritance of DNA methylation

Seung Cho Lee, Dexter W. Adams, Jonathan J. Ipsaro, Jonathan Cahn, Jason S. Lynn, Hyun Soo Kim, Benjamin Berube, Viktoria Major, Joseph P. Calarco, Chantal LeBlanc, Sonali Bhattacharjee, Umamaheswari Ramu, Daniel Grimanelli, Yannick Jacob, Philipp Voigt, , Robert A. Martienssen

The paper shows that DDM1 remodels histone H3 variants to facilitate epigenetic inheritance of DNA methylation by interacting with specific histone modifications and variants.

Cell · Aug 28, 2023Peer-reviewedMolecular Biology

A circadian-like gene network regulates heterochronic miRNA transcription in C. elegans

Brian A. Kinney, Shubham Sahu, Natalia Stec, Kelly Hills-Muckey, Dexter W. Adams, Jing Wang, Matt J. Jaremko, Leemor Joshua‐Tor, Wolfgang W. Keil, Christopher M. Hammell

The paper shows that NHR-85 and NHR-23 heterodimers regulate lin-4 miRNA transcription pulses in C. elegans, similar to circadian clock mechanisms in mammals.

bioRxiv · Sep 26, 2022 · PreprintDevelopmental Biology