Y. Mei

Differently sized soluble α-synuclein species from multiple system atrophy and Lewy body disease brains display different seeding propensities

This study compares soluble α-synuclein species from MSA and LBD brains, finding differences in their seeding activity and size distribution.

Force-Enhanced Sensitive Detection of New DNA-Interactive Agents from Microorganisms at the Single-Molecule Level

This paper introduces a single-molecule stretching assay to detect DNA-intercalating agents from microorganisms, identifying two strains and three compounds with anti-cancer activity.

A Stapled Peptide Inhibitor of METTL3-METTL14 for Cancer Therapy

This paper develops a stapled peptide inhibitor of METTL3-METTL14 that suppresses tumor growth by inhibiting m6A methylation and promoting METTL3 degradation.

Intervertebral Disc Elastography to Relate Shear Modulus and Relaxometry in Compression and Bending

This study relates shear modulus and relaxometry in intervertebral discs under compression and bending to assess degeneration.

DOCK2-deficiency causes defects in anti-viral T cell responses and poor control of herpes simplex virus infection

This study shows that DOCK2-deficient mice have impaired anti-viral CD8+ T cell responses and poor control of HSV-1 infection due to defects in clonal expansion and effector function.

Development of an affinity-enhanced clinical candidate TCR targeting NY-ESO-1 with optimal potency and high specificity

This study develops a high-affinity, specific TCR targeting NY-ESO-1 through engineering and screening, showing efficacy in tumor models and approval for clinical trials.

IL-12/18/21 pre-activation enhances the anti-tumor efficacy of expanded γδT cells and overcomes resistance to anti-PD-L1 treatment

This study shows that pre-activating γδT cells with IL-12/18/21 enhances their anti-tumor activity and overcomes resistance to anti-PD-L1 therapy in mouse models.

Human Cardiac Organoids to Model COVID-19 Cytokine Storm Induced Cardiac Injuries

This study uses human cardiac organoids to model COVID-19-induced cardiac injuries by simulating cytokine storm effects and evaluates potential therapeutic interventions.

Computational modeling of macrophage iron sequestration during host defense against Aspergillus

The paper develops a computational model of macrophage iron sequestration during Aspergillus infection, showing that transferrin receptor-1 upregulation precedes inflammatory cytokine induction.

Potential inhibitors for blocking the interaction of the coronavirus SARS-CoV-2 spike protein and its host cell receptor ACE2

This paper identifies TS-984 as a potent inhibitor of the SARS-CoV-2 spike protein-ACE2 interaction through a high-throughput screening platform and in vitro validation.

General Finite-Element Framework of the Virtual Fields Method in Nonlinear Elasticity

This paper introduces a general finite-element framework for the Virtual Fields Method to identify constitutive parameters in nonlinear elasticity using measured deformation fields.

MMP12 Knockout Prevent Weight and Muscle Loss Induced by Cancer Cachexia

This study shows that MMP12 knockout prevents weight and muscle loss in ApcMin/+ mice with cancer cachexia by disrupting insulin and glycolipid metabolism.

Cytoplasmic and nuclear Sw-5b NLR act both independently and synergistically to dictate full host defense against tospovirus infection

This study shows that the tomato NLR Sw-5b acts in both cytoplasm and nucleus to provide full resistance against tospovirus by blocking different infection stages.

Inhibition of IL-1beta secretion and mitochondria respiration by arsenite which acts on myocardial ischemia-reperfusion injury

The paper investigates arsenite's effects on IL-1beta secretion, mitochondrial respiration, and myocardial ischemia-reperfusion injury in rats.

High-glucose Induces Retinal Pigment Epithelium Mitochondrial Pathways of Apoptosis and Inhibits Mitophagy by Regulating ROS/PINK1/Parkin Signal Pathway

This study shows high-glucose induces RPE apoptosis and inhibits mitophagy by disrupting the ROS/PINK1/Parkin pathway.