Author

Ayako Sakamoto

RIKEN Center for Biosystems Dynamics ResearchORCID 0000-0002-9040-429XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Takuhiro ItoiD· 3 shared Kazuhiro KashiwagiiD· 2 shared Madoka NishimotoiD· 2 shared Mari TakahashiiD· 2 shared Akihide YoshimiiD· 1 shared Akinobu MatsumotoiD· 1 shared Atsushi HatanoiD· 1 shared Chisa ShiraishiiD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersMolecular Biology

Takuhiro ItoORCID

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3 papers

Recent·Most cited

Physiological mapping and prediction reveal stress-responsive translation initiation landscapes

Kazuya Ichihara, Taichi Shiraishi, Haruhiko Morita, Chisa Shiraishi, Mina Hirata, Naoto Yamashiki, Selena Setsu, Kotaro Tsuboyama, Atsushi Hatano, Serina Tokita, Emi Mishiro-Sato, Ayako Sakamoto, Takuhiro Ito, Kazumi Abe, Masahide Seki, , Akinobu Matsumoto

This study introduces TISCA2 and IncepTIS to map and predict stress-responsive translation initiation sites, revealing tissue-specific patterns and enabling engineered mRNA 5' leaders.

bioRxiv · Nov 5, 2026 · PreprintMolecular Biology

eIF2B-capturing viral protein NSs suppresses the integrated stress response

Kazuhiro Kashiwagi, Yuichi Shichino, Tatsuya Osaki, Ayako Sakamoto, Madoka Nishimoto, Mari Takahashi, Mari Mito, Friedemann Weber, Yoshiho Ikeuchi, Shintaro Iwasaki, Takuhiro Ito

This study identifies SFSV NSs as a viral protein that suppresses the integrated stress response by binding to eIF2B and preventing eIF2(P) from inhibiting nucleotide exchange.

Nature Communications · Dec 7, 2021Peer-reviewedMolecular Biology

Structural Basis for eIF2B Inhibition in Integrated Stress Response

Kazuhiro Kashiwagi, Takeshi Yokoyama, Madoka Nishimoto, Mari Takahashi, Ayako Sakamoto, Mayumi Yonemochi, Mikako Shirouzu, Takuhiro Ito

The paper determines cryo-EM and crystal structures of eIF2B with phosphorylated and unphosphorylated eIF2 to reveal how eIF2 phosphorylation inhibits eIF2B activity.

Science · May 2, 2019Peer-reviewedMolecular Biology