Maria Ciofani

The paper identifies multi-enhancer regulatory hubs critical for Th17 cell identity by analyzing chromatin accessibility and enhancer function in mouse CD4+ T cell subsets.

This study identifies an AP-1 regulatory axis that restricts Tγδ17 cell plasticity by stabilizing type 3 identity and preventing conversion to type 1 effectors during infection.

This paper designs and synthesizes C22- and C32-modified FK520 analogs with enhanced antifungal activity and reduced immunosuppression by leveraging structural insights from fungal and human CaN-FKBP12 complexes.

This paper describes the generation of two transgenic mouse lines for in vivo epigenome editing using CRISPR-based systems to activate or repress gene expression.

The paper develops methods to infer transcriptional regulatory networks in Th17 cells using ATAC-seq and RNA-seq data, revealing new roles for transcription factors and their modules.