Circadian modulation of neurons and astrocytes controls synaptic plasticity in hippocampal area CA1
John P. McCauley, Maurice A. Petroccione, Lianna Y. D’Brant, Gabrielle C. Todd, Nurat Affinnih, Justin J. Wisnoski, Shergil Zahid, Swasti Shree, Alioscka A. Sousa, Rose M. De Guzman, Rosanna Migliore, Alexey Brazhe, Richard D. Leapman, Alexander T. Khmaladze, Alexey V. Semyanov, , Annalisa Scimemi
The paper shows circadian rhythms in hippocampal CA1 neurons and astrocytes affect synaptic plasticity through changes in NMDA receptor expression and astrocytic proximity to synapses, altering glutamate clearance and cognitive processing.
Cell Reports · Oct 1, 2020Peer-reviewedNeuroscience