Simona Lodato

This study shows that early ASO treatment rescues developmental defects in SMA organoids by restoring SMN levels and correcting splicing defects.

The paper identifies human-specific enrichment of schizophrenia risk genes in callosal neurons of the developing neocortex using comparative transcriptomic analysis across species and developmental stages.

This study uses in vivo Perturb-Seq to analyze the effects of 35 autism risk genes on neuronal and glial cells in the developing brain.

The paper shows that transient maternal IL-6 elevation during early neurodevelopment disrupts hippocampal connectivity and enhances glutamatergic synapses in offspring through the STAT3/RGS4 pathway.

This study identifies temporally divergent regulatory mechanisms in neuronal development and maturation across mouse and marmoset neocortex.