Jacob A. Beierle

This study uses automated behavioral quantification to show that opioid withdrawal behaviors vary with genetic background, but severity can still be assessed within strains.

This study examines ultrasonic vocalizations (USVs) in FVB/N mouse pups during neonatal opioid withdrawal, identifying syllable sequences and acoustic properties linked to withdrawal severity.

The paper validates Zhx2 as a quantitative trait gene influencing brain oxymorphone levels and opioid behavior through genetic and multi-omics analyses in mice.

This study examines USV profiles and kappa opioid receptor involvement in neonatal opioid withdrawal in female mice, finding increased Complex 3 syllables and female-specific KOR system activation.

This study examines the effects of prenatal morphine exposure on neonatal behavior and transcriptome in mice, finding myelin gene downregulation but no long-term behavioral impacts in adulthood.

The paper identifies a Gabra2 variant that increases methamphetamine sensitivity using QTL analysis in mice and validates it with CRISPR correction.

This study investigates sex differences in behavioral and brainstem transcriptomic changes in mice exposed to neonatal opioids, finding sex-specific neuroadaptations linked to NOWS-like behaviors.

The paper identifies a dynamic hnRNP H RNA targetome in the striatum that responds to methamphetamine, affecting gene expression and behavior.

The paper identifies 5' UTR variants in Hnrnph1 that reduce 5' UTR usage and hnRNP H protein levels, linking these changes to reduced methamphetamine sensitivity.

This study shows that cuprizone reduces binge eating specifically in male C57BL/6NJ mice, suggesting sex-specific mechanisms influenced by genetic background.

This study identifies a mutation in Hnrnph1 that reduces methamphetamine-induced reinforcement, reward, and dopamine release while increasing synaptic hnRNP H and mitochondrial proteins in mice.

This study shows that Cyfip1 haploinsufficiency increases compulsive-like behavior and modulates palatable food intake in a parent-of-origin and genetic background-dependent manner in mice.

The paper examines changes in hnRNP H localization in primary rat cortical neurons after D1 dopamine receptor activation, finding increased nuclear immunostaining of the C-terminal domain without changes in protein levels.