Megan K. Mulligan

This study identifies time-dependent epistatic interactions between Oprm1 and Fgf12 that modulate opioid-induced locomotion in mice and links Fgf12 to opioid behavior in humans.

This study shows that female rats with paternal WMI lineage exhibit increased oxycodone consumption and accelerated escalation compared to reciprocal offspring, indicating a parent-of-origin effect in addiction vulnerability.

This study shows CBD modulates THC-induced behavioral changes in mice, varying by dose, sex, and genetic background, with no effect on antinociception.

This study shows that enriched environment reverses early-onset memory deficits in middle-aged WMI female rats, with associated changes in estradiol and mitochondrial function.

The paper investigates genetic and sex differences in stress and morphine responses across mouse strains and their progeny, finding genetic influences on stress vulnerability and morphine sensitivity.

The paper compares risky decision-making and impulsivity between two Lewis rat substrains, finding significant phenotypic differences linked to genetic variants.

This study uses LMM-MQM time series mapping to identify additional QTLs for body weight in mice, improving the explained variance of a known locus and detecting novel loci.

The paper identifies a Gabra2 variant that increases methamphetamine sensitivity using QTL analysis in mice and validates it with CRISPR correction.

The paper examines how diet and genetics interact to affect longevity and weight gain in mice, finding that genetic differences significantly influence the impact of high-fat diets on lifespan.

The paper quantifies heritability of THC responses in BXD mice strains and identifies candidate genes associated with variation in initial sensitivity to THC effects.

The paper uses whole genome sequencing to compare nearly isogenic WMI and WLI inbred rats, identifying genetic variants associated with depression and stress-related traits.

This study identifies Gabra2 as a genetic modifier of Dravet syndrome in mice by showing that a deletion in Gabra2 worsens seizure and survival phenotypes in Scn1a+/- mice, which is reversed by repairing the deletion.

The paper identifies genetic loci influencing binge-like eating in mice using a cross between C57BL/6J and DBA/2J strains, finding sex-specific and combined QTLs.

GeneCup mines PubMed for gene relationships using a custom ontology and deep learning to organize and present relevant literature and GWAS results.

The paper presents two computational methods to reduce contamination in single-cell RNA-seq data, improving clustering and biological interpretation.

The paper identifies Kcnn3 as a pharmacogenetic target for reducing ethanol drinking and anxiety-like behaviors in stressed, ethanol-dependent mice.

This study shows that Cyfip1 haploinsufficiency increases compulsive-like behavior and modulates palatable food intake in a parent-of-origin and genetic background-dependent manner in mice.

BXD mouse family doubled to 150 inbred strains segregating over 6 million variants, with roughly 10,000 located recombinations and a public phenome exceeding 7000 traits.

The paper identifies a functional non-coding variant in the GABRA2 gene of the C57BL/6J mouse strain, showing its impact on Gabra2 expression and implications for neuroscience research.

The paper identifies a major QTL on chromosome 7 associated with acute thermal nociception in C57BL/6 mouse substrains.