Cell BiologyJournal of HepatologyPeer-reviewed
✦ In-depth digest
PNPLA3(148M) Promotes Hepatic Steatosis by Interfering with Triglyceride Hydrolysis Through a Gain-of-Function Mechanism
Yang Wang, Sen Hong, Hannah Hudson…·Helen H. Hobbs
ABHD5 binds PNPLA3 more strongly than ATGL regardless of the I148M variant; steatosis from PNPLA3(148M) needs ATGL and is reversed by ABHD5 overexpression.