Joseph W. Thrush

This study shows that Gag proteolysis drives HIV-1 Env conformational closure through the gp41 cytoplasmic tail, revealing a mechanism for immune evasion.

The paper uses cryo-electron tomography to study NiV fusion protein assemblies and shows nanobodies block inter-trimer interactions, inhibiting viral entry.

Alpha-BET uses AlphaFold to identify optimal sites for labeling viral glycoproteins with nanobodies, enabling high-resolution imaging of viral structures without disrupting their function.