Marc Torrent

Seven amino acids gate transcriptional activation by a minimal MarA Helix turn-helix DNA-binding domain

The paper shows that a single HTH domain from MarA can bind DNA and activate transcription when properly dimerized, revealing structural insights for synthetic biology applications.

The N-terminal helix of MarA as a key element in the mechanism of DNA binding

This study identifies the N-terminal helix of MarA as critical for DNA binding, showing its role in recognizing marboxes and suggesting it as a target for antibiotic resistance inhibitors.

Mining the heparinome for cryptic antimicrobial peptides that selectively kill gram-negative bacteria

The paper identifies antimicrobial peptides from heparin-binding proteins that selectively kill gram-negative bacteria by binding to LPS.

The PRALINE database: Protein and Rna humAn singLe nucleotIde variaNts in condEnsates

PRALINE is a database that catalogs proteins and RNAs in biological condensates, their interactions, and the impact of single-nucleotide variants on condensate properties.

Interplay between disordered regions in RNAs and proteins modulates interactions within stress granules and processing bodies

The paper investigates the structural properties of proteins and RNAs in stress granules and processing bodies, finding that intrinsic disorder and single-stranded regions mediate dynamic interactions.

RNA-Binding and Prion Domains: The Yin and Yang of Phase Separation

The paper investigates how Prion-Like Domains (PrLDs) and RNA-Binding Domains (RBDs) contribute to biomolecular condensation in human and yeast proteomes.

The fitness cost and benefit of phase separated protein deposits

The paper quantifies the fitness costs and benefits of protein deposit formation via phase separation in yeast, showing environmental and functional demands influence fitness outcomes and generate phenotypic variability.